靶点确定和验证

对潜在的药物靶点进行生物化学、结构和功能表征对于治疗药物的发现和开发是必要的,这些表征有助于对活性进行合理优化。

我们的专家技术系列产品为研究者们提供有价值的疾病病理靶点的深入了解,以及对涉及的生物学过程和关键分子通路的更好的了解。这些工具包括细胞成像平台,比如IN Cell Analyzer高内涵分析系统以及用于确定活性结合浓度和表征未标记分子相互作用的Biacore表面等离子共振技术。

Biacore表面等离子共振(SPR)系统

当对结合物和孤儿受体(配体垂钓)进行筛选时,Biacore系统能直接在天然的细胞和组织匀浆中检测特异性结合。捕获配体能从生物传感器表面回收,并且已经被确定的鉴定无需要进一步的纯化,既节省了时间,又节省了宝贵的样品。

IN Cell Analyzer高内涵分析(HCA)系统

高内涵分析为体外结合和酶学分析做补充。这项技术被广泛用于探索靶点与特定疾病的相关性、检测它调节生物学过程的能力以及确认相互作用在患病细胞中产生的期望的功效。IN Cell Analyzer系统完美地适用于大规模分析,包括用于鉴定涉及特定机理中的一系列基因的基因组规模的RNAi筛选,或者是为那些以前没有发现明确作用的筛选做注解。

Filter papers for technical use

Grade Typical Thickness (µm) Basis Weight (g/m²) Flow Rate / Aspect Nominal Particle Retention in Liquid* (µm) Prepleated Grade
0858 170 75 Medium fast, grained 12 Grade 0858 ½
0860 170 75 Medium fast, smooth 12 Grade 0860 ½
0903 140 65 Medium to slow, smooth 7  
0905 270 75 Very fast, creped 25 Grade 0905 ½
1574 160 90 Medium fast, very low fiber release 12 Grade 1574 ½
2294 1500 556 Fast, wet strength, thick 15  
2589 a 430 200 Medium fast, wet strength 12  
2589 c 750 400 Medium to slow, wet strength 8  
2589 d 1000 500 Medium to slow, wet strength, thick 6  
520 a 300 90 Very fast, creped, high wet strength 18 Grade 520 a ½
520 bII 500 135 Very fast, creped, wet strength, thick 19 Grade 520 bII ½
Shark Skin 170 44 Medium to slow, wet strength, thin, creped 12  

*Particle retention rating at 98% efficiency.

Application specific filters

Grade Typical Thickness (µm) Basis Weight (g/m²) Flow Rate / Aspect Examples of Applications / Properties
3000 160 68 Fast, smooth Sugar industry 
3459 300 75 Fast, creped Venema unit
512 ½ 160 84 Low phosphate Soil analysis—Low phosphate
2555 ½ 170 75 Medium fast Malt and beer testing
287 ½ 360 154   Kieselguhr paper
0048 860 130   Food industry mat
72 800 195   Activated carbon loaded paper

Please note that this data may be based on historic performance, which was established before Whatman was acquired by GE Healthcare.

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